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I remember seeing this video the first time when I was still just a second year PhD student and I was blown away. The video is from a paper published in the journal Nature Communication entitled: Real-space and Real-time dynamics of CRISPR-Cas9 visualised by high-speed atomic force microscopy. CRISPR-Cas9 is a genome editing technology that has 2 main components: a Cas9 enzyme that can cut DNA (nuclease), and a guide RNA called single-guide RNA (or sgRNA). The guide RNA acts like a compass that
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CRISPR… but make it ✨precise✨ Forget cutting DNA—CRISPR base editing is here to re-write the genetic script! 🎯✍️ 💡 Instead of breaking the double helix to make edits (knock-outs or knock-ins), base editors chemically convert one base to another—like A ➡️ G or C ➡️ T. 👩🔬 Scientists disable to the ✂️ function of the Cas9 protein and FUSE it to a protein that processes this chemical conversion (deaminase) 🧠 Think: molecular pencil ✏️, not scissors! CRISPR base editing is perfect for fixing po
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